kebuzone

Also known as ketophenylbutazone, 4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione, 1,2-Diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione

Kebuzone (or ketophenylbutazone) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the treatment of inflammatory conditions such as thrombophlebitis and rheumatoid arthritis (RA).

In the Vinony graph

Vinony's link graph records 166 inbound references to kebuzone, and connects out to medication, kidney and International Standard Book Number.

It is catalogued under topics including Drugboxes which contain changes to verified fields, Drugboxes which contain changes to watched fields and Drugs with no legal status.

Vinony links it to 6 Wikipedia language editions.

Chemical data

Formula: C19H18N2O3
Molecular weight: 322.4 g/mol
IUPAC name: 4-(3-oxobutyl)-1,2-diphenylpyrazolidine-3,5-dione
SMILES: CC(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
InChIKey: LGYTZKPVOAIUKX-UHFFFAOYSA-N
XLogP: 1.2
Polar surface area: 57.7 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule
Indications: rheumatic disease

via ChEMBL · EBI

Research

28 papers

Binding of kebuzone to human serum albumin studied by high performance liquid affinity chromatography.Arzneimittel-Forschung · 2000
Solid-phase extraction and HPLC analysis of kebuzone and its metabolites in blood.Die Pharmazie · 1996
[HPLC analysis of nonsteroidal antirheumatic agents in biological materials. III. Pyrazolidinediones].Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti · 1998
The use of borohydrides of alkaline metals in the volumetric analysis of medicaments.Die Pharmazie · 1977
Determination of some non-steroid anti-inflammatory drugs by capillary isotachophoresis.Journal of pharmaceutical and biomedical analysis · 1995

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 322.131742

Show 5 more facts

chemical formula: C₁₉H₁₈N₂O₃
NCI Thesaurus ID: C79126
canonical SMILES: CC(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
World Health Organisation international non-proprietary name: kebuzone
subject has role: non-steroidal anti-inflammatory drug

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

1 sections

Contents

References

Kebuzone (or ketophenylbutazone) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the treatment of inflammatory conditions such as thrombophlebitis and rheumatoid arthritis (RA).

==References==

Excerpted from Wikipedia’s “kebuzone” article, available under the CC BY-SA 4.0 licence.