KLK1
Sign in to saveAlso known as KLKR, Klk6, hK1, kallikrein 1
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.
In the Vinony graph
Within Vinony's link graph, KLK1 is referenced by 138 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.
Vinony files it under EC 3.1.21, Genes on human chromosome 19 and Proteases.
Its subject is documented across 6 Wikipedia language editions.
Gene data
KLK1- Name
- kallikrein 1
- Type
- protein-coding
- Position
- 50,819,146–50,823,787 (−)
- Aliases
- KLKR, Klk6, hK1
- Ensembl
- ENSG00000167748
- RefSeq RNA
- NM_002257.4
- RefSeq protein
- NP_002248.1
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
kallikrein 1
- Symbol
- KLK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:50,819,146-50,823,787
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein KLK1 PDB 1spj.png
Show 8 more facts
- HomoloGene ID
- 110727
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3816
- genomic end
- 51327043
- genomic start
- 50819146
- chromosome
- human chromosome 19
- cytogenetic location
- 19q13.33
- expressed in
- gonad
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- See also
- References
- Further reading
- External links
Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Excerpted from Wikipedia’s “KLK1” article, available under the CC BY-SA 4.0 licence.