latrepirdine
Sign in to saveLatrepirdine (INN, also known as dimebolin and sold as Dimebon) is an antihistamine drug which has been used clinically in Russia since 1983.
Wikidata facts
- Mass
- 319.205
Show 3 more facts
- chemical formula
- C₂₁H₂₅N₃
- canonical SMILES
- CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CN=C(C=C4)C
- Commons category
- Latrepirdine
Sources (2)
via Wikidata · CC0
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Article
7 sectionsContents
- Uses
- Clinical trials
- Alzheimer's disease
- Huntington's disease
- Pharmacology
- See also
- References
Latrepirdine (INN, also known as dimebolin and sold as Dimebon) is an antihistamine drug which has been used clinically in Russia since 1983.
Research was conducted in both Russia and western nations into potential applications as a neuroprotective drug to treat Alzheimer's disease and, possibly, as a nootropic, as well. After a major phase III clinical trial for Alzheimer's disease (AD) treatment failed to show any benefit, three other AD trials continued. Major industry-based development in this indication essentially stopped after another Phase III trial suffered the same fate in 2012. Latrepirdine failed in the phase III trial for Huntington's disease.