licofelone

Also known as LCF, ML3000

Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

In the Vinony graph

Within Vinony's link graph, licofelone is referenced by 215 other articles, and connects out to prostaglandin-endoperoxide synthase, clonixin and selenium.

Vinony files it under Abandoned drugs, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.

Its subject is documented across 6 Wikipedia language editions.

Chemical data

Formula: C23H22ClNO2
Molecular weight: 379.9 g/mol
IUPAC name: 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
SMILES: CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
InChIKey: UAWXGRJVZSAUSZ-UHFFFAOYSA-N
XLogP: 5.2
Polar surface area: 42.2 Å²
H-bond donors: 1
H-bond acceptors: 2
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Research

157 papers

Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders.Prostaglandins & other lipid mediators · 2021
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.Rheumatology (Oxford, England) · 2004
Licofelone--a novel analgesic and anti-inflammatory agent.Current topics in medicinal chemistry · 2007
Poly-beta-amino-ester licofelone conjugates development for osteoarthritis treatment.RSC advances · 2024
Licofelone Attenuates Acetic Acid-Induced Colitis in Rats Through Suppression of the Inflammatory Mediators.Inflammation · 2023

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 379.13390662399996

Show 3 more facts

chemical formula: C₂₃H₂₂ClNO₂
canonical SMILES: CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
Commons category: Licofelone

Sources (2)

via Wikidata · CC0

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Encyclopedic overview

1 sections

Contents

References

Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-lipoxygenase (5-LOX) may reduce the gastrointestinal toxicity associated with other nonsteroidal anti-inflammatory drugs (NSAID), which only inhibit cyclooxygenase (COX). Licofelone is the first drug to inhibit both.

Excerpted from Wikipedia’s “licofelone” article, available under the CC BY-SA 4.0 licence.