LIM2

Also known as CTRCT19, MP17, MP19, lens intrinsic membrane protein 2

Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.

Gene data

LIM2

Name: lens intrinsic membrane protein 2
Type: protein-coding
Aliases: CTRCT19, MP17, MP19

This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009].

via MyGene.info

Gene · Ensembl

lens intrinsic membrane protein 2

Symbol: LIM2
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:51,379,909-51,388,264
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 12744
exact match: identifiers.org/ncbigene/3982
genomic end: 51387974
genomic start: 51379909
cytogenetic location: 19q13.41

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Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.

The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of cataracts, e.g., crystalline-gamma-1 (CRYG1; MIM 123660). The second most abundant intrinsic membrane protein of the lens fiber cell is MP19, so named for major lens protein having a molecular weight of 19.5 kD.