MRPS22

Also known as C3orf5, COXPD5, GIBT, MRP-S22, RPMS22, GK002, mitochondrial ribosomal protein S22, ODG7

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 208 inbound references to MRPS22, and connects out to mitochondrion, PubMed and protein biosynthesis.

It sits within the topics Genes on human chromosome 3 and Ribosomal proteins.

Vinony links it to 6 Wikipedia language editions.

Gene data

MRPS22

Name: mitochondrial ribosomal protein S22
Type: protein-coding
Position: 139,005,806–139,360,497 (+)
Aliases: C3orf5, COXPD5, GIBT, GK002, MRP-S22, ODG7, RPMS22, mS22
Ensembl: ENSG00000175110
RefSeq RNA: NM_001363857.1, NM_001363893.1, NM_020191.4
RefSeq protein: NP_001350786.1, NP_001350822.1, NP_064576.1

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A pseudogene corresponding to this gene is found on chromosome Xq. [provided by RefSeq, Jul 2008].