Structure via PubChem · Public domain (PubChem)
nimustine
Sign in to saveNimustine () is a nitrosourea alkylating agent.
In the Vinony graph
Vinony's link graph records 273 inbound references to nimustine, and connects out to tiazofurin, medication and digital object identifier.
It sits within the topics Alkylating antineoplastic agents, Chemical pages without DrugBank identifier and Chloroethyl compounds.
Vinony links it to 8 Wikipedia language editions.
Chemical data
- Formula
- C9H13ClN6O2
- Molecular weight
- 272.69 g/mol
- IUPAC name
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitrosourea
- SMILES
- CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O
- InChIKey
- VFEDRRNHLBGPNN-UHFFFAOYSA-N
- XLogP
- 0.4
- Polar surface area
- 114 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- neoplasm, glioblastoma multiforme
via ChEMBL · EBI
Research
951 papers- Therapeutic effect of nimustine in a dog with intracranial histiocytic sarcoma.Open veterinary journal · 2024
- Nimustine Treatment of 11 Cases of Canine Histiocytic Sarcoma.Journal of the American Animal Hospital Association · 2020
- Retrospective evaluation of nimustine use in the treatment of feline lymphoma.Veterinary medicine and science · 2022
- Local Delivery of Nimustine Hydrochloride against Brain Tumors: Basic Characterization Study.The Tohoku journal of experimental medicine · 2023
- Regression of Recurrent Spinal Cord High-Grade Glioma After Convection-Enhanced Delivery of Nimustine Hydrochloride: Case Reports and Literature Review.Operative neurosurgery (Hagerstown, Md.) · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 272.078851
- Has use
- medication
Show 4 more facts
- chemical formula
- C₉H₁₃ClN₆O₂
- canonical SMILES
- CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O
- Commons category
- Nimustine
- subject has role
- antineoplastic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Nimustine () is a nitrosourea alkylating agent.
It is used to treat malignant brain tumors and has proven to be rather effective.
Excerpted from Wikipedia’s “nimustine” article, available under the CC BY-SA 4.0 licence.
Available in 8 languages
via Wikidata sitelinks · CC0
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