PARP2
Sign in to saveAlso known as ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2, poly(ADP-ribose) polymerase 2
Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of the PARP family of enzymes.
In the Vinony graph
Vinony's link graph records 10 inbound references to PARP2, and connects out to PubMed, human chromosome 14 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 14.
Vinony links it to 6 Wikipedia language editions.
Gene data
PARP2- Name
- poly(ADP-ribose) polymerase 2
- Type
- protein-coding
- Position
- 20,343,541–20,362,074 (+)
- Aliases
- ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
- Ensembl
- ENSG00000291803
- RefSeq RNA
- NM_001042618.2, NM_005484.4, XM_005267247.4, XM_017020912.2, XM_047430869.1
- RefSeq protein
- NP_001036083.1, NP_005475.2, XP_005267304.1, XP_016876401.1, XP_047286825.1
This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
poly(ADP-ribose) polymerase 2
- Symbol
- PARP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:20,343,541-20,362,074
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein PARP2 PDB 1gs0.png
Show 8 more facts
- HomoloGene ID
- 4004
- genomic start
- 20811741
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/10038
- genomic end
- 20357904
- chromosome
- human chromosome 14
- cytogenetic location
- 14q11.2
- Commons category
- PARP2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Function
- PARP inhibitor drugs
- Interactions
- References
- Further reading
- External links
Poly [ADP-ribose] polymerase 2 is an enzyme that in humans is encoded by the PARP2 gene. It is one of the PARP family of enzymes.
== Function ==
Excerpted from Wikipedia’s “PARP2” article, available under the CC BY-SA 4.0 licence.