perospirone

Also known as Lullan® (Japan), SM-9018, cis-N-(4-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)butyl)-1,2-cyclohexanedicarboximide

Perospirone (Lullan) is an atypical antipsychotic of the azapirone family. It was introduced in Japan by Dainippon Sumitomo Pharma in 2001 for the treatment of schizophrenia and acute cases of bipolar mania.

In the Vinony graph

Within Vinony's link graph, perospirone is referenced by 1,932 other articles, and connects out to propranolol, fluphenazine and zuclopenthixol.

It sits within the topics Atypical antipsychotics, Azapirones and Chemical pages without DrugBank identifier.

Its subject is documented across 11 Wikipedia language editions.

Chemical data

Formula: C23H30N4O2S
Molecular weight: 426.6 g/mol
IUPAC name: (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
SMILES: C1CC[C@H]2[C@@H](C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
InChIKey: FBVFZWUMDDXLLG-HDICACEKSA-N
XLogP: 3.9
Polar surface area: 85 Å²
H-bond donors: 0
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Research

176 papers

Perospirone.CNS drugs · 2001
Perospirone (Sumitomo Pharmaceuticals).Current opinion in investigational drugs (London, England : 2000) · 2002
[Pharmacological characteristics of perospirone hydrochloride, a novel antipsychotic agent].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 2000
Antihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain.Pharmacology, biochemistry, and behavior · 2020
Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.CNS drugs · 2013

via PubMed

Wikidata facts

Subclass of: heterocyclic compound
Mass: 426.208947
Has use: medication

Show 5 more facts

subject has role: antipsychotics
chemical formula: C₂₃H₃₀N₄O₂S
isomeric SMILES: C1CC[C@H]2[C@@H](C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
canonical SMILES: C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54
Commons category: Perospirone

Sources (2)

via Wikidata · CC0

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