PINK1
Sign in to saveAlso known as BRPK, PARK6, PTEN induced putative kinase 1, PTEN induced kinase 1
PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.
In the Vinony graph
Vinony's link graph records 28 inbound references to PINK1, and connects out to PubMed, Ensembl genome database project and Parkin RBR E3 ubiquitin protein ligase.
Vinony files it under Genes on human chromosome 1 and Parkinson's disease.
Vinony links it to 7 Wikipedia language editions.
Gene data
PINK1- Name
- PTEN induced kinase 1
- Type
- protein-coding
- Position
- 20,633,436–20,652,231 (+)
- Aliases
- BRPK, PARK6
- Ensembl
- ENSG00000158828
- RefSeq RNA
- NM_032409.3
- RefSeq protein
- NP_115785.1
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
PTEN induced kinase 1
- Symbol
- PINK1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:20,633,436-20,652,231
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Research
5,736 papers- The role of PINK1-Parkin in mitochondrial quality control.Nature cell biology · 2024
- PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.Acta neuropathologica communications · 2020
- PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models.Autophagy · 2023
- Activation mechanism of PINK1.Nature · 2022
- Deciphering the Molecular Signals of PINK1/Parkin Mitophagy.Trends in cell biology · 2016
via PubMed
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 32672
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/65018
- genomic end
- 20978004
- genomic start
- 20633458
- chromosome
- human chromosome 1
- cytogenetic location
- 1p36.12
- expressed in
- nucleus accumbens
via Wikidata · CC0
~6 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Disease relevance
- Pharmacological manipulation
- References
- Further reading
- External links
PTEN-induced kinase 1 (PINK1) is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene.
It is thought to protect cells from stress-induced mitochondrial dysfunction. PINK1 activity causes the parkin protein to bind to depolarized mitochondria to induce autophagy of those mitochondria. PINK1 is processed by healthy mitochondria and released to trigger neuron differentiation. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson's disease.
Excerpted from Wikipedia’s “PINK1” article, available under the CC BY-SA 4.0 licence.