POLH

Also known as RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta

protein-coding gene in the species Homo sapiens

Gene data

POLH

Name: DNA polymerase eta
Type: protein-coding
Aliases: RAD30, RAD30A, XP-V, XPV

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].

via MyGene.info