ROM1

Also known as ROM, ROSP1, RP7, TSPAN23, retinal outer segment membrane protein 1

Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene.

Gene data

ROM1

Name: retinal outer segment membrane protein 1
Type: protein-coding
Position: 62,611,722–62,615,116 (+)
Aliases: ROM, ROSP1, RP7, TSPAN23
Ensembl: ENSG00000149489
RefSeq RNA: NM_000327.4
RefSeq protein: NP_000318.2

This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

visual perception visual perception

Molecular function

protein binding protein homodimerization activity

Cellular component

photoreceptor outer segment plasma membrane plasma membrane membrane photoreceptor outer segment membrane

via MyGene.info

Gene · Ensembl

retinal outer segment membrane protein 1

Symbol: ROM1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:62,611,722-62,615,116
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 276
exact match: identifiers.org/ncbigene/6094
genomic end: 62615116
genomic start: 62379194
cytogenetic location: 11q12.3

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Rod outer segment membrane protein 1 is a protein that in humans is encoded by the ROM1 gene.

This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor protein, peripherin-2 (PRPH2; retinal degeneration, slow; RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa.