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GeneQ18048102· pop 5· linked from 43 articles

SIGLEC10

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Also known as PRO940, SIGLEC-10, SLG2, sialic acid binding Ig like lectin 10

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

Gene data

SIGLEC10
Name
sialic acid binding Ig like lectin 10
Type
protein-coding
Position
51,410,020–51,417,858 (−)
Aliases
PRO940, SIGLEC-10, SLG2
Ensembl
ENSG00000142512
RefSeq RNA
NM_001171156.2, NM_001171157.2, NM_001171158.2, NM_001171159.2, NM_001171160.1
RefSeq protein
NP_001164627.1, NP_001164628.1, NP_001164629.1, NP_001164630.1, NP_001164632.1

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002].

Gene Ontology

Pathways

Adaptive Immune SystemImmune SystemImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

via MyGene.info

Gene · Ensembl

sialic acid binding Ig like lectin 10

Symbol
SIGLEC10
Biotype
Protein coding
Organism
Homo sapiens
Location
19:51,410,020-51,417,858
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

4 sections
Contents
  • Structure and function
  • Gene family summary
  • References
  • Further reading

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

== Structure and function== Like most but not all other Siglecs, Siglec-10 bears an ITIM (Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).

Excerpted from Wikipedia’s “SIGLEC10” article, available under the CC BY-SA 4.0 licence.

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