SIN3B

Name

SIN3 transcription regulator family member B

Type

protein-coding

Position

16,829,387–16,880,355 (+)

Ensembl

ENSG00000127511

RefSeq RNA

NM_001297595.2, NM_001297597.2, NM_015260.4, XM_006722704.2, XM_054320368.1

RefSeq protein

NP_001284524.1, NP_001284526.1, NP_056075.1, XP_006722767.1, XP_054176343.1

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

via MyGene.info

Gene · Ensembl

SIN3 transcription regulator family member B

Symbol

SIN3B

Biotype

Protein coding

Organism

Homo sapiens

Location

19:16,829,387-16,880,355

Strand

Forward (+)

Assembly

GRCh38

• SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
• Knockout of SIN3B modulates transcriptional programs and cell survival in cutaneous melanoma.Pharmacological research · 2025
• The potential of targeting Sin3B and its associated complexes for cancer therapy.Expert opinion on therapeutic targets · 2017
• SIN3B promotes integrin αV subunit gene transcription and cell migration of hepatocellular carcinoma.Journal of molecular cell biology · 2019
• Chromatin-Associated SIN3B Protects Cancer Cells from Genotoxic Stress-Induced Apoptosis and Dictates DNA Damage Repair Pathway Choice.Molecular cancer research : MCR · 2023

via PubMed

Wikidata facts

Image

Protein SIN3B PDB 1e91.png

via Wikidata · CC0