thrombomodulin
Sign in to saveAlso known as THBD, fetomodulin, CD141 antigen
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
Protein · UniProt
Thrombomodulin
- Gene
- THBD
- Organism
- Homo sapiens (Human)
- Length
- 575 aa
- Molecular mass
- 60,329 Da
- Evidence
- 1: Evidence at protein level
Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis (PubMed:10761923). Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway (PubMed:29323190, PubMed:33836597, PubMed:9395524). Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or an…
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
16 registered- TERMINATEDComparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ FailureAssistance Publique - Hôpitaux de Paris · NCT00361725
- NACOMPLETEDSevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.University of Chile · NCT03772054
- COMPLETEDThrombomodulin-modified Thrombin Generation Assay (TGA-TM) in Patients With Critical InfectionsMedical University of Vienna · NCT04356144
- NACOMPLETEDAnticoagulation, Vitamins, and Endothelial FunctionUS Department of Veterans Affairs · NCT00018460
- TERMINATEDEffects of Oxygen on Lung Tissue During AnesthesiaVanderbilt University · NCT00715338
- UNKNOWNThe Diagnostic and Prognostic Value of TAT, PIC, tPAI·C and TM in Sepsis-induced CoagulopathyThe First Hospital of Jilin University · NCT06379126
~2 min read
Article
6 sectionsContents
- Genetics and structure
- Function
- Interactions
- References
- Further reading
- External links
Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is also expressed on human mesothelial cell, monocyte and a dendritic cell subset.
== Genetics and structure ==