TNNT2
Sign in to saveAlso known as CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT, troponin T2, cardiac type
thumb|327x327px|Cardiac sarcomere structure, featuring troponin T Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
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Within Vinony's link graph, TNNT2 is referenced by 278 other articles, and connects out to hair keratin, PubMed and myosin.
It is catalogued under the topic Genes on human chromosome 1.
Its subject is documented across 7 Wikipedia language editions.
Gene data
TNNT2- Name
- troponin T2, cardiac type
- Type
- protein-coding
- Position
- 201,356,606–201,379,773 (−)
- Aliases
- CMD1D, CMH2, CMPD2, LVNC6, RCM3, TnTC, cTnT
- Ensembl
- ENSG00000118194
- RefSeq RNA
- NM_000364.4, NM_001001430.3, NM_001001431.3, NM_001001432.3, NM_001276345.2
- RefSeq protein
- NP_000355.2, NP_001001430.1, NP_001001431.1, NP_001001432.1, NP_001263274.1
This gene encodes the cardiac isoform of troponin T. The encoded protein is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. [provided by RefSeq, May 2022].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
troponin T2, cardiac type
- Symbol
- TNNT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:201,356,606-201,379,773
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNNT2 PDB 1j1d.png
Show 8 more facts
- HomoloGene ID
- 68050
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7139
- genomic end
- 201377764
- genomic start
- 201328136
- chromosome
- human chromosome 1
- cytogenetic location
- 1q32.1
- genetic association
- hypertrophic cardiomyopathy
via Wikidata · CC0
~12 min read
Encyclopedic overview
15 sectionsContents
- Structure
- Function
- Clinical significance
- Reference values
- Elevated levels after COVID-19 mRNA vaccinations
- Evolution
- Alternative splicing
- Posttranslational modifications
- Phosphorylation
- O-linked GlcNAcylation
- Proteolytic modification
- Mutations in cardiomyopathies
- Notes
- References
- External links
thumb|327x327px|Cardiac sarcomere structure, featuring troponin T Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.
The TNNT2 gene is located at 1q32 in the human chromosomal genome, encoding the cardiac muscle isoform of troponin T (cTnT). Human cTnT is an ~36-kDa protein consisting of 297 amino acids including the first methionine with an isoelectric point (pI) of 4.88. It is the tropomyosin- binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells. TNNT2 gene is expressed in vertebrate cardiac muscles and embryonic skeletal muscles.
Excerpted from Wikipedia’s “TNNT2” article, available under the CC BY-SA 4.0 licence.