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GeneQ4682273· pop 8· linked from 508 articles

ADORA2B

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Also known as ADORA2, adenosine A2b receptor

protein-coding gene in the species Homo sapiens

Gene data

ADORA2B

Name: adenosine A2b receptor
Type: protein-coding
Position: 15,945,130–15,975,746 (+)
Aliases: ADORA2
Ensembl: ENSG00000170425
RefSeq RNA: NM_000676.4, XM_011523659.4, XM_011523661.3, XM_017024197.3, XM_047435373.1
RefSeq protein: NP_000667.1, XP_011521961.1, XP_011521963.1, XP_016879686.1, XP_047291329.1

This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

G protein-coupled adenosine receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway activation of adenylate cyclase activity vasodilation presynaptic modulation of chemical synaptic transmission

Molecular function

G protein-coupled adenosine receptor activity G protein-coupled adenosine receptor activity G protein-coupled receptor activity protein binding

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane membrane synapse Schaffer collateral - CA1 synapse presynapse

Pathways

Rap1 signaling pathway - Homo sapiens (human)Calcium signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)Alcoholism - Homo sapiens (human)Signal Transduction Disease Signaling by GPCR Class A/1 (Rhodopsin-like receptors)GPCR downstream signalling

via MyGene.info

Gene · Ensembl

adenosine A2b receptor

Symbol: ADORA2B
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:15,945,093-15,976,467
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 20167
exact match: identifiers.org/ncbigene/136
genomic end: 15879060
genomic start: 15945130
cytogenetic location: 17p12

Sources (4)

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Categories

Adenosine receptors Genes on human chromosome 17