ATF2

Name

activating transcription factor 2

Type

protein-coding

Position

175,072,250–175,168,382 (−)

Aliases

CRE-BP1, CREB-2, CREB2, HB16, TREB7

Ensembl

ENSG00000115966

RefSeq RNA

NM_001256090.2, NM_001256091.2, NM_001256092.2, NM_001256093.2, NM_001256094.2

RefSeq protein

NP_001243019.1, NP_001243020.1, NP_001243021.1, NP_001243022.1, NP_001243023.1

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

activating transcription factor 2

Symbol

ATF2

Biotype

Protein coding

Organism

Homo sapiens

Location

2:175,072,250-175,168,382

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ATF2 PDB 1bhi.png

via Wikidata · CC0