Structure via PubChem · Public domain (PubChem)
azosemide
Sign in to saveAlso known as 5-(4'-chloro-5'-sulfamoyl-2'-thenylaminophenyl)tetrazole, Diart, 2-chloro-5-(1H-tetrazol-5-yl)-N(4)-2-thenylsulfanilamide
Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim. As of 2015 it was available as a generic in some Asian countries.
In the Vinony graph
Within Vinony's link graph, azosemide is referenced by 75 other articles, and connects out to collecting duct system, medication and International Standard Book Number.
Vinony files it under Diuretics, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C12H11ClN6O2S2
- Molecular weight
- 370.8 g/mol
- IUPAC name
- 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide
- SMILES
- C1=CSC(=C1)CNC2=CC(=C(C=C2C3=NNN=N3)S(=O)(=O)N)Cl
- InChIKey
- HMEDEBAJARCKCT-UHFFFAOYSA-N
- XLogP
- 1.5
- Polar surface area
- 163 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
120 papers- Pharmacokinetics and pharmacodynamics of azosemide.Biopharmaceutics & drug disposition · 2003
- Azosemide kinetics and dynamics.Clinical pharmacology and therapeutics · 1983
- Pharmacokinetics and pharmacodynamics of azosemide after intravenous and oral administration to rats: absorption from various GI segments.Journal of pharmacokinetics and biopharmaceutics · 1996
- The loop diuretic torasemide but not azosemide potentiates the anti-seizure and disease-modifying effects of midazolam in a rat model of birth asphyxia.Epilepsy & behavior : E&B · 2023
- Circadian changes in the pharmacokinetics and pharmacodynamics of azosemide in rats.The Journal of pharmacy and pharmacology · 1998
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 370.007
Show 5 more facts
- Commons category
- Azosemide
- chemical formula
- C₁₂H₁₁ClN₆O₂S₂
- canonical SMILES
- C1=CSC(=C1)CNC2=CC(=C(C=C2C3=NNN=N3)S(=O)(=O)N)Cl
- World Health Organisation international non-proprietary name
- azosemide
- subject has role
- diuretic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Azosemide is a high-ceiling loop diuretic agent that was brought to market in 1981 by Boehringer Mannheim. As of 2015 it was available as a generic in some Asian countries.
Azosemide has been found as an adulterant in ketamine. ==References==
Excerpted from Wikipedia’s “azosemide” article, available under the CC BY-SA 4.0 licence.