CENPM
Sign in to saveAlso known as C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
In the Vinony graph
Within Vinony's link graph, CENPM is referenced by 75 other articles, and connects out to chromosome, centromeric region, PubMed and human chromosome 22.
It is catalogued under the topic Genes on human chromosome 22.
Its subject is documented across 5 Wikipedia language editions.
Gene data
CENPM- Name
- centromere protein M
- Type
- protein-coding
- Position
- 41,927,514–41,947,183 (−)
- Aliases
- C22orf18, CENP-M, PANE1
- Ensembl
- ENSG00000100162
- RefSeq RNA
- NM_001002876.3, NM_001110215.3, NM_001304370.2, NM_001304371.2, NM_001304372.2
- RefSeq protein
- NP_001002876.1, NP_001103685.1, NP_001291299.1, NP_001291300.1, NP_001291301.1
The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology
Biological process
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
centromere protein M
- Symbol
- CENPM
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:41,927,514-41,947,183
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 11438
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79019
- genomic end
- 41947152
- genomic start
- 41938737
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.2
- expressed in
- appendix
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.
An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells. Centromere protein M is involved in centromere assembly and immune response.
Excerpted from Wikipedia’s “CENPM” article, available under the CC BY-SA 4.0 licence.