CENPT

Also known as C16orf56, CENP-T, centromere protein T, SSMGA

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

In the Vinony graph

Vinony's link graph records 76 inbound references to CENPT, and connects out to chromosome, centromeric region, PubMed and human chromosome 16.

It is catalogued under the topic Genes on human chromosome 16.

Vinony links it to 5 Wikipedia language editions.

Gene data

CENPT

Name: centromere protein T
Type: protein-coding
Position: 67,828,157–67,847,811 (−)
Aliases: C16orf56, CENP-T, SSMGA
Ensembl: ENSG00000102901
RefSeq RNA: NM_025082.4, XM_017023717.2, XM_024450455.2, XM_024450456.2, XM_047434686.1
RefSeq protein: NP_079358.3, XP_016879206.1, XP_024306223.1, XP_024306224.1, XP_047290642.1

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008].

Gene Ontology

Biological process

mitotic cell cycle mitotic cell cycle chromosome segregation chromosome segregation chromosome segregation chromosome organization kinetochore assembly kinetochore assembly

Molecular function

DNA binding protein binding protein heterodimerization activity

Cellular component

chromosome, centromeric region chromosome, centromeric region kinetochore kinetochore inner kinetochore nucleus nucleus nucleoplasm

Pathways

Amplification of signal from the kinetochores Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Signal Transduction Cell Cycle Signaling by Rho GTPases RHO GTPase Effectors Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Metaphase and Anaphase RHO GTPases Activate Formins

via MyGene.info

Gene · Ensembl

centromere protein T

Symbol: CENPT
Biotype: Protein coding
Organism: Homo sapiens
Location: 16:67,828,157-67,847,811
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 41610
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/80152
genomic end: 67881714
genomic start: 67862060
chromosome: human chromosome 16
cytogenetic location: 16q22.1

Sources (4)

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Encyclopedic overview

5 sections

Contents

Clinical significance
See also
References
External links
Further reading

Centromere protein T is a protein that in humans is encoded by the CENPT gene.

== Clinical significance == Mutations in CENPT cause an autosomal recessive syndrome of microcephaly, short stature, skeletal abnormalities, underdeveloped genitalia and pubertal delay.

Excerpted from Wikipedia’s “CENPT” article, available under the CC BY-SA 4.0 licence.