Structure via PubChem · Public domain (PubChem)
chlorproethazine
Sign in to saveChlorproethazine, sold under the brand name Neuriplege, is a drug of the phenothiazine group described as a muscle relaxant or tranquilizer which is or has been marketed in Europe as a topical cream for the treatment of muscle pain. It has been associated with photoallergic contact dermatitis. ==Synthesis== Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps.
In the Vinony graph
Within Vinony's link graph, chlorproethazine is referenced by 447 other articles, and connects out to Ullmann condensation, Europe and International Standard Book Number.
Vinony files it under Analgesics, Chemical articles with multiple CAS registry numbers and Chemical articles with multiple compound IDs.
Its subject is documented across 7 Wikipedia language editions.
Chemical data
- Formula
- C19H23ClN2S
- Molecular weight
- 346.9 g/mol
- IUPAC name
- 3-(2-chlorophenothiazin-10-yl)-N,N-diethylpropan-1-amine
- SMILES
- CCN(CC)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
- InChIKey
- DBOUGBAQLIXZLV-UHFFFAOYSA-N
- XLogP
- 5.9
- Polar surface area
- 31.8 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- psychosis
via ChEMBL · EBI
Research
16 papers- Phenothiazines boost host control of Mycobacterium avium infection in primary human macrophages.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
- Photocontact allergic and phototoxic studies of chlorproethazine.Photodermatology, photoimmunology & photomedicine · 2008
- Photodermatitis from topical phenothiazines: A case series.Contact dermatitis · 2020
- Contact sensitization to chlorproethazine can induce persistent light reaction and cross-photoreactions to other phenothiazines.Contact dermatitis · 2001
- [Chlorproethazine. Its importance in neurology].La Presse medicale · 1961
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 346.127
Show 3 more facts
- chemical formula
- C₁₉H₂₃ClN₂S
- canonical SMILES
- CCN(CC)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl
- Commons category
- Chlorproethazine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
Chlorproethazine, sold under the brand name Neuriplege, is a drug of the phenothiazine group described as a muscle relaxant or tranquilizer which is or has been marketed in Europe as a topical cream for the treatment of muscle pain. It has been associated with photoallergic contact dermatitis. ==Synthesis== Chlorproethazine can be synthesized from a diphenylsulfide derivative. The general scheme is sufficiently flexible to permit the interchange of the order of some of the steps.
thumb|center|500px|Patent:
Excerpted from Wikipedia’s “chlorproethazine” article, available under the CC BY-SA 4.0 licence.