DGCR8

Also known as C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, DGCR8, microprocessor complex subunit

protein-coding gene in the species Homo sapiens

Gene data

DGCR8

Name: DGCR8 microprocessor complex subunit
Type: protein-coding
Position: 20,080,035–20,111,877 (+)
Aliases: C22orf12, DGCRK6, Gy1, pasha
Ensembl: ENSG00000128191
RefSeq RNA: NM_001190326.2, NM_022720.7, XM_006724268.4, XM_047441418.1, XM_047441419.1
RefSeq protein: NP_001177255.1, NP_073557.3, XP_006724331.1, XP_047297374.1, XP_047297375.1

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].