EDNRB
Sign in to saveAlso known as ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2
protein-coding gene in the species Homo sapiens
Gene data
EDNRB- Name
- endothelin receptor type B
- Type
- protein-coding
- Position
- 77,895,481–77,975,529 (−)
- Aliases
- ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
- Ensembl
- ENSG00000136160
- RefSeq RNA
- NM_000115.5, NM_001122659.3, NM_001201397.2, NM_003991.4, NR_047024.1
- RefSeq protein
- NP_000106.1, NP_001116131.1, NP_001188326.1, NP_003982.1
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIrenin secretion into blood streamregulation of heart ratecGMP biosynthetic processcell surface receptor signaling pathwayG protein-coupled receptor signaling pathway
Molecular function
Pathways
Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Melanogenesis - Homo sapiens (human)Relaxin signaling pathway - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Developmental BiologySignal TransductionSignaling by GPCRClass A/1 (Rhodopsin-like receptors)
via MyGene.info
Gene · Ensembl
endothelin receptor type B
- Symbol
- EDNRB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 13:77,895,481-77,975,529
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 89
- exact match
- identifiers.org/ncbigene/1910
- genomic end
- 77975529
- genomic start
- 78469616
- cytogenetic location
- 13q22.3
via Wikidata · CC0
Connections
Q180686
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Ensembl genome database project
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