ebastine

Ebastine is a H1 antihistamine with low potential for causing drowsiness.

In the Vinony graph

Within Vinony's link graph, ebastine is referenced by 345 other articles, and connects out to (RS)-meclizine, cytochrome P450 family 3 subfamily A member 4 and South Africa.

Vinony files it under Aromatic ketones, Chemical pages without DrugBank identifier and Drugs with no legal status.

Its subject is documented across 22 Wikipedia language editions.

Key facts

Drug.verifiedrevid: 439227374
Drug.IUPAC_name: 4-(4-benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one
Drug.image: Ebastine.svg
Drug.image_class: skin-invert-image
Drug.caption: Above: molecular structure of ebastine Below: 3D representation of an ebastine molecule
Drug.image2: Ebastine 3D.png
Drug.image_class2: bg-transparent
Drug.routes_of_administration: Oral
Drug.protein_bound: Greater than 95%
Drug.metabolism: Hepatic (CYP3A4-mediated), to carebastine
Drug.elimination_half life: 15 to 19 hours (carebastine)
Drug.CAS_number: 90729-43-4
Drug.ATC_prefix: R06
Drug.ATC_suffix: AX22
Drug.PubChem: 3191
Drug.ChemSpiderID: 3079
Drug.UNII: TQD7Q784P1
Drug.ChEMBL: 305660

via Wikipedia infobox

Chemical data

Formula: C32H39NO2
Molecular weight: 469.7 g/mol
IUPAC name: 4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one
SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
InChIKey: MJJALKDDGIKVBE-UHFFFAOYSA-N
XLogP: 7.2
Polar surface area: 29.5 Å²
H-bond donors: 0
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1990
Admin. routes: oral
Indications: allergic disease, irritable bowel syndrome

via ChEMBL · EBI

Research

398 papers

Ebastine.2006
Ebastine: an update of its use in allergic disorders.Drugs · 2000
Ebastine in allergic rhinitis and chronic idiopathic urticaria.Allergy · 2008
Ebastine in the Treatment of Allergic Rhinitis and Urticaria: 30 Years of Clinical Studies and Real-World Experience.Journal of investigational allergology & clinical immunology · 2020
Cardiac effects of ebastine and other antihistamines in humans.Drug safety · 1999

via PubMed

Wikidata facts

Mass: 469.298
Has use: medication

Show 6 more facts

chemical formula: C₃₂H₃₉NO₂
canonical SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
defined daily dose: 10
route of administration: oral administration
subject has role: H1 antagonist
Commons category: Ebastine

Sources (3)

via Wikidata · CC0

~2 min read

Encyclopedic overview

7 sections

Contents

Uses
Safety
Pharmacokinetic profile
Brand names
See also
References
External links

Ebastine is a H1 antihistamine with low potential for causing drowsiness.

It does not penetrate the blood–brain barrier to a significant amount and thus combines an effective block of the H1 receptor in peripheral tissue with a low incidence of central side effects, i.e. seldom causing sedation or drowsiness.

Excerpted from Wikipedia’s “ebastine” article, available under the CC BY-SA 4.0 licence.