ETS1

Also known as ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.

Gene data

ETS1

Name: ETS proto-oncogene 1, transcription factor
Type: protein-coding
Position: 128,458,761–128,587,606 (−)
Aliases: ETS-1, EWSR2, c-ets-1, p54
Ensembl: ENSG00000134954
RefSeq RNA: NM_001143820.2, NM_001162422.2, NM_001330451.2, NM_005238.4, XM_011542650.2
RefSeq protein: NP_001137292.1, NP_001155894.1, NP_001317380.1, NP_005229.1, XP_011540952.1

This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II immune response negative regulation of cell population proliferation positive regulation of endothelial cell migration positive regulation of gene expression

Molecular function

transcription cis-regulatory region binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm

Pathways

Ras signaling pathway - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Human T-cell leukemia virus 1 infection - Homo sapiens (human)Pathways in cancer - Homo sapiens (human)Renal cell carcinoma - Homo sapiens (human)Developmental Biology Cellular responses to stress Cellular Senescence Oncogene Induced Senescence Cellular responses to stimuli

via MyGene.info

Gene · Ensembl

ETS proto-oncogene 1, transcription factor

Symbol: ETS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:128,458,761-128,587,611
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ETS1 PDB 1bqv.png

Show 5 more facts

HomoloGene ID: 3837
exact match: identifiers.org/ncbigene/2113
genomic end: 128457453
genomic start: 128328656
cytogenetic location: 11q24.3

Sources (7)

via Wikidata · CC0

~7 min read

Article

10 sections

Contents

Function
Knockout mice
Clinical significance
Interactions
Interaction with DNA repair promoters and proteins
DNA repair promoters
DNA repair protein interactions
References
Further reading
External links

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.

== Function ==