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Structure via PubChem · Public domain (PubChem)
fluproquazone
Sign in to saveFluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz. It was withdrawn during development due to liver toxicity.
Chemical data
- Formula
- C18H17FN2O
- Molecular weight
- 296.3 g/mol
- IUPAC name
- 4-(4-fluorophenyl)-7-methyl-1-propan-2-ylquinazolin-2-one
- SMILES
- CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
- InChIKey
- ZWOUXWWGKJBAHQ-UHFFFAOYSA-N
- XLogP
- 4.1
- Polar surface area
- 32.7 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
28 papers- Fluproquazone (Tormosyl).Arzneimittel-Forschung · 1981
- Fluproquazone for osteoarthritis.Rheumatology and rehabilitation · 1981
- Toxicological evaluation of fluproquazone.Arzneimittel-Forschung · 1981
- Analgesic effect of fluproquazone in postoperative patients.Clinical pharmacology and therapeutics · 1980
- Antipyretic activity of fluproquazone in man.Arzneimittel-Forschung · 1981
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 296.132
Show 3 more facts
- chemical formula
- C₁₈H₁₇FN₂O
- canonical SMILES
- CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=C(C=C3)F
- subject has role
- non-steroidal anti-inflammatory drug
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Fluproquazone (trade name Tormosyl, RF 46-790 ) was a quinazolinone derivative with potent analgesic, antipyretic, and anti-inflammatory effects discovered by Sandoz. It was withdrawn during development due to liver toxicity.
== References ==
Excerpted from Wikipedia’s “fluproquazone” article, available under the CC BY-SA 4.0 licence.