GNA11
Sign in to saveAlso known as FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2, G protein subunit alpha 11, HG1K
Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.
Gene data
GNA11- Name
- G protein subunit alpha 11
- Type
- protein-coding
- Position
- 3,094,320–3,124,001 (+)
- Aliases
- FBH, FBH2, FHH2, GNA-11, HG1K, HHC2, HYPOC2
- Ensembl
- ENSG00000088256
- RefSeq RNA
- NM_002067.5
- RefSeq protein
- NP_002058.2
The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
G protein subunit alpha 11
- Symbol
- GNA11
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:3,094,320-3,124,001
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- See also
- References
- Further reading
Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.
==See also== Gq alpha subunit
Excerpted from Wikipedia’s “GNA11” article, available under the CC BY-SA 4.0 licence.
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