GNAI3

Name

G protein subunit alpha i3

Type

protein-coding

Position

109,548,584–109,600,195 (+)

Aliases

87U6, ARCND1, ARCODS, HG1A

Ensembl

ENSG00000065135

RefSeq RNA

NM_006496.4

RefSeq protein

NP_006487.1

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012].