GNG3

Also known as G protein subunit gamma 3, HG3D

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

In the Vinony graph

Within Vinony's link graph, GNG3 is referenced by 88 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 5 Wikipedia language editions.

Gene data

GNG3

Name: G protein subunit gamma 3
Type: protein-coding
Position: 62,706,400–62,712,083 (+)
Aliases: HG3D
Ensembl: ENSG00000162188
RefSeq RNA: NM_012202.5, XM_006718500.3, XM_047426794.1, XM_054368463.1, XM_054368464.1
RefSeq protein: NP_036334.1, XP_006718563.1, XP_047282750.1, XP_054224438.1, XP_054224439.1

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration

Molecular function

GTPase activity G protein activity protein binding G-protein beta-subunit binding

Cellular component

heterotrimeric G-protein complex heterotrimeric G-protein complex plasma membrane plasma membrane postsynaptic density dendrite cell body synapse

Pathways

Ras signaling pathway - Homo sapiens (human)Chemokine signaling pathway - Homo sapiens (human)PI3K-Akt signaling pathway - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Circadian entrainment - Homo sapiens (human)Retrograde endocannabinoid signaling - Homo sapiens (human)Glutamatergic synapse - Homo sapiens (human)Cholinergic synapse - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)GABAergic synapse - Homo sapiens (human)

via MyGene.info

Gene · Ensembl

G protein subunit gamma 3

Symbol: GNG3
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:62,706,400-62,712,083
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 22575
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2785
genomic end: 62476673
genomic start: 62707676
chromosome: human chromosome 11
cytogenetic location: 11q12.3
expressed in: ganglionic eminence

Sources (4)

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Encyclopedic overview

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Contents

References
Further reading

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene.

G proteins are heterotrimers of alpha, beta, and gamma subunits. Gamma subunits, such as GNG3, contribute to the specificity of the hundreds of receptor signaling pathways involving G proteins (Schwindinger et al., 2004).[supplied by OMIM]

Excerpted from Wikipedia’s “GNG3” article, available under the CC BY-SA 4.0 licence.