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GeneQ14907967· pop 8· linked from 322 articles

GRK2

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Also known as BARK1, BETA-ARK1, ADRBK1, G protein-coupled receptor kinase 2

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 322 inbound references to GRK2, and connects out to PubMed, Ensembl genome database project and protein-serine-threonine kinases.

It sits within the topics EC 2.7.11, Genes on human chromosome 11 and Protein kinases.

Vinony links it to 7 Wikipedia language editions.

Gene data

GRK2

Name: G protein-coupled receptor kinase 2
Type: protein-coding
Position: 67,266,351–67,286,562 (+)
Aliases: ADRBK1, BARK1, BETA-ARK1
Ensembl: ENSG00000173020
RefSeq RNA: NM_001619.5, XM_011544773.2, XM_054367819.1, XR_007062455.1, XR_008488347.1
RefSeq protein: NP_001610.2, XP_011543075.1, XP_054223794.1

This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017].

Gene Ontology

Biological process

regulation of the force of heart contraction desensitization of G protein-coupled receptor signaling pathway desensitization of G protein-coupled receptor signaling pathway desensitization of G protein-coupled receptor signaling pathway desensitization of G protein-coupled receptor signaling pathway desensitization of G protein-coupled receptor signaling pathway negative regulation of the force of heart contraction by chemical signal signal transduction

Molecular function

G protein-coupled receptor binding protein kinase activity protein kinase activity protein kinase activity protein serine/threonine kinase activity G protein-coupled receptor kinase activity G protein-coupled receptor kinase activity G protein-coupled receptor kinase activity

Cellular component

cytoplasm cytoplasm cytoplasm cytosol cytosol plasma membrane plasma membrane plasma membrane

Pathways

Chemokine signaling pathway - Homo sapiens (human)Endocytosis - Homo sapiens (human)Hedgehog signaling pathway - Homo sapiens (human)Glutamatergic synapse - Homo sapiens (human)Olfactory transduction - Homo sapiens (human)Morphine addiction - Homo sapiens (human)Opioid Signalling Calmodulin induced events Ca-dependent events CaM pathway

via MyGene.info

Gene · Ensembl

G protein-coupled receptor kinase 2

Symbol: GRK2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:67,266,351-67,286,562
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Described at

uniprot.org →

Link to a page describing this subject · not written by Vinony

Wikidata facts

Instance of: gene
Image: Protein ADRBK1 PDB 1bak.png

Show 10 more facts

HomoloGene ID: 1223
genomic end: 67286556
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/156
genomic start: 67266473
chromosome: human chromosome 11
cytogenetic location: 11q13.2
Commons category: Beta adrenergic receptor kinase
described at URL: www.uniprot.org/uniprot/P25098
expressed in: gallbladder

Sources (6)

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Available in 7 languages

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Categories

EC 2.7.11 Genes on human chromosome 11 Protein kinases Proteins Transferases