HDAC10
Sign in to saveAlso known as HD10, histone deacetylase 10
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.
In the Vinony graph
Vinony's link graph records 65 inbound references to HDAC10, and connects out to PubMed, human chromosome 22 and Ensembl genome database project.
Vinony files it under EC 3.5.1 and Genes on human chromosome 22.
Vinony links it to 6 Wikipedia language editions.
Gene data
HDAC10- Name
- histone deacetylase 10
- Type
- protein-coding
- Position
- 50,245,183–50,251,407 (−)
- Aliases
- HD10
- Ensembl
- ENSG00000100429
- RefSeq RNA
- NM_001159286.2, NM_032019.6
- RefSeq protein
- NP_001152758.1, NP_114408.3
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
histone deacetylase 10
- Symbol
- HDAC10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:50,245,183-50,251,407
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 23749
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/83933
- genomic end
- 50689834
- genomic start
- 50683612
- chromosome
- human chromosome 22
- cytogenetic location
- 22q13.33
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Interactions
- See also
- References
- Further reading
- External links
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.
Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]
Excerpted from Wikipedia’s “HDAC10” article, available under the CC BY-SA 4.0 licence.