HDAC10

Also known as HD10, histone deacetylase 10

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.

Gene data

HDAC10

Name: histone deacetylase 10
Type: protein-coding
Position: 50,245,183–50,251,405 (−)
Aliases: HD10
Ensembl: ENSG00000100429
RefSeq RNA: NM_001159286.2, NM_032019.6
RefSeq protein: NP_001152758.1, NP_114408.3

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

Pathways

Neutrophil extracellular trap formation - Homo sapiens (human)Alcoholism - Homo sapiens (human)Viral carcinogenesis - Homo sapiens (human)Developmental Biology Signaling by NOTCH Signal Transduction Disease Signaling by NOTCH1 NOTCH1 Intracellular Domain Regulates Transcription Generic Transcription Pathway

via MyGene.info

Gene · Ensembl

histone deacetylase 10

Symbol: HDAC10
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:50,245,183-50,251,407
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 23749
exact match: identifiers.org/ncbigene/83933
genomic end: 50689834
genomic start: 50683612
cytogenetic location: 22q13.33

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Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]