IL33
Sign in to saveAlso known as C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin 33, IL-33, IL-1F11
protein-coding gene in the species Homo sapiens
Gene data
IL33- Name
- interleukin 33
- Type
- protein-coding
- Position
- 6,215,136–6,257,983 (+)
- Aliases
- C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
- Ensembl
- ENSG00000137033
- RefSeq RNA
- NM_001199640.2, NM_001199641.2, NM_001314044.2, NM_001314045.2, NM_001314046.2
- RefSeq protein
- NP_001186569.1, NP_001186570.1, NP_001300973.1, NP_001300974.1, NP_001300975.1
The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IIpositive regulation of cytokine productionmacrophage activation involved in immune responsemicroglial cell activation involved in immune responsenegative regulation of immunoglobulin productionpositive regulation of immunoglobulin productionnegative regulation of leukocyte migrationnegative regulation of T-helper 1 type immune response
Molecular function
Pathways
Cytokine-cytokine receptor interaction - Homo sapiens (human)Necroptosis - Homo sapiens (human)Cytosolic DNA-sensing pathway - Homo sapiens (human)Influenza A - Homo sapiens (human)PIP3 activates AKT signalingCytokine Signaling in Immune systemSignal TransductionImmune SystemNegative regulation of the PI3K/AKT networkMetabolism of proteins
via MyGene.info
Gene · Ensembl
interleukin 33
- Symbol
- IL33
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:6,215,136-6,281,596
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- 2KLL.pdb.png
Show 5 more facts
- HomoloGene ID
- 14126
- exact match
- identifiers.org/ncbigene/90865
- genomic end
- 6257983
- genomic start
- 6215805
- cytogenetic location
- 9p24.1
Sources (8)
via Wikidata · CC0
Connections
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interleukin-1 family
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Q180686
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Ensembl genome database project
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human interleukin 17
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IL1RN
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Interleukin 1-alpha
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TXLNA
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IL1RL1
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IL1F10
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protein
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International Standard Book Number
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Wikidata
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gene
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chromosome
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pathology
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public domain
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digital object identifier
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