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GeneQ18046059· pop 5· linked from 815 articles

IRX1

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Also known as IRX-5, IRXA1, iroquois homeobox 1

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning. IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.

Gene data

IRX1
Name
iroquois homeobox 1
Type
protein-coding
Position
3,595,832–3,601,408 (+)
Aliases
IRX-5, IRXA1
Ensembl
ENSG00000170549
RefSeq RNA
NM_024337.4
RefSeq protein
NP_077313.3

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011].

Gene Ontology

Cellular component

chromatinnucleusnucleus

Pathways

Developmental BiologyKidney developmentNephron development

via MyGene.info

Gene · Ensembl

iroquois homeobox 1

Symbol
IRX1
Biotype
Protein coding
Organism
Homo sapiens
Location
5:3,595,832-3,601,408
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~7 min read

Encyclopedic overview

13 sections
Contents
  • Role in development
  • Gene
  • Overview
  • Gene neighborhood
  • Expression
  • Protein
  • Properties and characteristics
  • Protein Interactions
  • Conservation
  • Orthologs
  • Paralogs
  • References
  • Further reading

Iroquois-class homeodomain protein IRX-1, also known as Iroquois homeobox protein 1, is a protein that in humans is encoded by the IRX1 gene. All members of the Iroquois (IRO) family of proteins share two highly conserved features, encoding both a homeodomain and a characteristic IRO sequence motif. Members of this family are known to play numerous roles in early embryo patterning. IRX1 has also been shown to act as a tumor suppressor gene in several forms of cancer.

== Role in development ==

Excerpted from Wikipedia’s “IRX1” article, available under the CC BY-SA 4.0 licence.

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