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モルヒネ

File:Morphine.svg · Wikimedia Commons · See Wikimedia Commons

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モルヒネ

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Also known as (-)-morphine, (5R,6S,9R,13S,14R)-4,5-epoxy-N-methyl-7-morphinen-3,6-diol, Morphia, morphium, (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol, (5alpha,6alpha)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, (5α,6α)-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline-7,9-diol

アヘンに含まれるアルカロイドの主成分

OverviewAI-generated

Morphine is a chemical compound with the formula C₁₇H₁₉NO₃. It was discovered in 1804. The compound has a mass of 285.136 and a melting point of 254. Its defined daily dose is 30.

The IUPAC name for morphine is (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol. It possesses a charge of 0, an xlogp of 0.8, and a tpsa of 52.9. The molecule contains two hydrogen bond donors and four hydrogen bond acceptors.

Synthesized by Vinony from 21 facts across 4 sources: Wikidata, PubChem, PubMed, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Drug.verifiedrevid
477170110
Drug.image
Morphine2DCSDS.svg
Drug.image_class
skin-invert-image
Drug.width
180
Drug.image2
Morphine molecule ball.png
Drug.image_class2
bg-transparent
Drug.tradename
Statex, MS Contin, Kadian, Oramorph, M-ESLON, others
Drug.MedlinePlus
a682133
Drug.DailyMedID
Morphine
Drug.pregnancy_AU
C
Drug.dependency_liability
High
Drug.addiction_liability
High
Drug.routes_of_administration
Inhalation, insufflation, by mouth, rectal, subcutaneous, intramuscular, intravenous, epidural, intrathecal
Drug.class
Opiate
Drug.ATC_prefix
N02
Drug.ATC_suffix
AA01
Drug.legal_AU
S8
Drug.legal_BR
A1

via Wikipedia infobox

Chemical data

Formula
C17H19NO3
Molecular weight
285.34 g/mol
IUPAC name
(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O
InChIKey
BQJCRHHNABKAKU-KBQPJGBKSA-N
XLogP
0.8
Polar surface area
52.9 Ų
H-bond donors
2
H-bond acceptors
4
Formal charge
0

via PubChem

Drug data · ChEMBL

Max clinical phase
Approved
Molecule type
Small molecule
First approval
1984
Admin. routes
oral, parenteral
Indications
pain, chronic obstructive pulmonary disease, injury, neoplasm

via ChEMBL · EBI

Research

82,258 papers

via PubMed

Wikidata facts

Has part
hydrogen
Mass
285.136
Has use
medication
Show 12 more facts
Commons category
Morphine
topic's main category
Category:Morphine
found in taxon
Physalis angulata
chemical formula
C₁₇H₁₉NO₃
medical condition treated
fibromyalgia
canonical SMILES
CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O
isomeric SMILES
CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O
melting point
254
time of discovery or invention
1804-00-00
subject has role
essential medicine
defined daily dose
30
significant drug interaction
gabapentin
Sources (8)

via Wikidata · CC0

Article · 日本語

モルヒネ（莫児比涅、蘭: morfine、英: morphine、英語発音: [ˈmɔːrfiːn]）は、ベンジルイソキノリン型アルカロイドの一種で、チロシンから生合成されるオピオイド系の化合物である。ケシを原料とする。脳内や脊髄に作用し、痛みを脳に伝える神経の活動を抑制し、鎮痛作用を示す。 極めて強力な鎮痛作用を持ち、日本では薬機法に定められた、重要な処方箋医薬品である。とくに持続する疼痛である鈍痛に効果が高く、一般的な鎮痛薬が効きにくい内臓痛をはじめ、各種がん性疼痛や手術後のにも適応する。有効限界がないのも特徴で、より強い痛みに対しては用量を増やすことによる対応が可能である。 その一方で適切に使わねば強い中毒性・常習性を持つため（医療の鎮痛目的には使用方法が確立されており、適切に使えば依存することはない）、毒薬（薬機法）・麻薬（麻向法）として規制されている。

Abstract from DBpedia / Wikipedia · CC BY-SA

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via Wikidata sitelinks · CC0