NFKBIE

Also known as IKBE, NFKB inhibitor epsilon

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.

In the Vinony graph

Vinony's link graph records 6 inbound references to NFKBIE, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 6.

Vinony links it to 5 Wikipedia language editions.

Gene data

NFKBIE

Name: NFKB inhibitor epsilon
Type: protein-coding
Position: 44,258,166–44,265,788 (−)
Aliases: IKBE
Ensembl: ENSG00000146232
RefSeq RNA: NM_004556.3
RefSeq protein: NP_004547.3

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011].

Gene Ontology

Molecular function

protein binding protein sequestering activity protein sequestering activity

Cellular component

fibrillar center nucleoplasm cytoplasm cytoplasm cytoplasm cytosol cytosol

Pathways

via MyGene.info

Gene · Ensembl

NFKB inhibitor epsilon

Symbol: NFKBIE
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:44,258,166-44,265,788
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 9 more facts

HomoloGene ID: 36160
chromosome: human chromosome 6
genetic association: rheumatoid arthritis
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/4794
genomic end: 44233500
genomic start: 44225903
cytogenetic location: 6p21.1
expressed in: blood

Sources (6)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.

== Function ==

Excerpted from Wikipedia’s “NFKBIE” article, available under the CC BY-SA 4.0 licence.