MAP3K14

Also known as FTDCR1B, HS, HSNIK, NIK, mitogen-activated protein kinase kinase kinase 14

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that in humans is encoded by the MAP3K14 gene.

In the Vinony graph

Vinony's link graph records 304 inbound references to MAP3K14, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.

Vinony files it under EC 2.7.11 and Genes on human chromosome 17.

Vinony links it to 5 Wikipedia language editions.

Gene data

MAP3K14

Name: mitogen-activated protein kinase kinase kinase 14
Type: protein-coding
Position: 45,263,119–45,317,112 (−)
Aliases: FTDCR1B, HS, HSNIK, IMD112, NIK
Ensembl: ENSG00000006062
RefSeq RNA: NM_003954.5, XM_011525441.3, XM_047436997.1, XM_047436998.1, XM_054317683.1
RefSeq protein: NP_003945.2, XP_011523743.1, XP_047292953.1, XP_047292954.1, XP_054173658.1

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

MAPK cascade immune response immune response non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction defense response to virus

Molecular function

protein kinase activity protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding

Cellular component

cytoplasm cytosol cytosol

Pathways

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase kinase kinase 14

Symbol: MAP3K14
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:45,263,119-45,317,112
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 2940
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/9020
chromosome: human chromosome 17
cytogenetic location: 17q21.31
genomic start: 45263119
genomic end: 45317029
expressed in: anterior pituitary

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
Interactions
References
Further reading

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that in humans is encoded by the MAP3K14 gene.

== Function ==

Excerpted from Wikipedia’s “MAP3K14” article, available under the CC BY-SA 4.0 licence.