MAP3K14

Also known as FTDCR1B, HS, HSNIK, NIK, mitogen-activated protein kinase kinase kinase 14

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that in humans is encoded by the MAP3K14 gene.

Gene data

MAP3K14

Name: mitogen-activated protein kinase kinase kinase 14
Type: protein-coding
Aliases: FTDCR1B, HS, HSNIK, IMD112, NIK

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

mitogen-activated protein kinase kinase kinase 14

Symbol: MAP3K14
Biotype: Protein coding
Organism: Homo sapiens
Location: 17:45,263,119-45,317,112
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2940
exact match: identifiers.org/ncbigene/9020
cytogenetic location: 17q21.31
genomic start: 45263119
genomic end: 45317029

Sources (3)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Function
Interactions
References
Further reading

Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that in humans is encoded by the MAP3K14 gene.

== Function ==