SHC1
Sign in to saveAlso known as SHC, SHCA, SHC adaptor protein 1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.
In the Vinony graph
Vinony's link graph records 52 inbound references to SHC1, and connects out to PubMed, human chromosome 1 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 1.
Vinony links it to 8 Wikipedia language editions.
Gene data
SHC1- Name
- SHC adaptor protein 1
- Type
- protein-coding
- Position
- 154,962,284–154,974,452 (−)
- Aliases
- SHC, SHCA
- Ensembl
- ENSG00000160691
- RefSeq RNA
- NM_001130040.2, NM_001130041.2, NM_001202859.2, NM_003029.5, NM_183001.5
- RefSeq protein
- NP_001123512.1, NP_001123513.1, NP_001189788.1, NP_003020.2, NP_892113.4
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
SHC adaptor protein 1
- Symbol
- SHC1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:154,962,284-154,974,452
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein SHC1 PDB 1mil.png
Show 9 more facts
- HomoloGene ID
- 7934
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6464
- genomic end
- 154946871
- genomic start
- 154934774
- chromosome
- human chromosome 1
- cytogenetic location
- 1q21.3
- Commons category
- SHC1
- expressed in
- canal of the cervix
Sources (4)
via Wikidata · CC0
~6 min read
Encyclopedic overview
10 sectionsContents
- Gene and expression
- Function
- EGFR pathway
- MCT-1 regulation
- Oxidative stress
- Life span
- p66SHC metabolism
- Clinical significance
- References
- Further reading
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene. SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells.
SCOP classifies the 3D structure as belonging to the SH2 domain family.
Excerpted from Wikipedia’s “SHC1” article, available under the CC BY-SA 4.0 licence.