SOST
Sign in to saveAlso known as CDD, SOST1, VBCH, DAND6, sclerostin, Sclerostin
Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation.
In the Vinony graph
Vinony's link graph records 43 inbound references to SOST, and connects out to PubMed, Ensembl genome database project and phase of clinical research.
It sits within the topics Genes on human chromosome 17, Human proteins and Osteopathies.
Vinony links it to 11 Wikipedia language editions.
Key facts
- Protein family.Symbol
- Sclerostin
- Protein family.Name
- Sclerostin
- Protein family.Pfam
- PF05463
- Protein family.InterPro
- IPR008835
via Wikipedia infobox
Gene data
SOST- Name
- sclerostin
- Type
- protein-coding
- Position
- 43,753,738–43,758,791 (−)
- Aliases
- CDD, DAND6, SOST1, VBCH
- Ensembl
- ENSG00000167941
- RefSeq RNA
- NM_025237.3
- RefSeq protein
- NP_079513.1
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
sclerostin
- Symbol
- SOST
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:43,753,738-43,758,791
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 2KD3.png
Show 8 more facts
- HomoloGene ID
- 11542
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/50964
- chromosome
- human chromosome 17
- genomic start
- 43753738
- genomic end
- 43758791
- cytogenetic location
- 17q21.31
- Commons category
- Sclerostin
via Wikidata · CC0
~4 min read
Encyclopedic overview
7 sectionsContents
- Structure
- Function
- Clinical significance
- Sclerostin antibody
- References
- Further reading
- External links
Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation.
== Structure ==
Excerpted from Wikipedia’s “SOST” article, available under the CC BY-SA 4.0 licence.