temoporfin

Also known as meso-tetrahydroxyphenylchlorin, 2,3-dihydro-5,10,15,20-tetra(m-hydroxyphenyl)porphyrin, m-THPC

Temoporfin (INN) is a photosensitizer (based on chlorin) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck. It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.

In the Vinony graph

Vinony's link graph records 275 inbound references to temoporfin, and connects out to tiazofurin, European Union and digital object identifier.

It sits within the topics Chemical pages without DrugBank identifier, Drug has EMA link and Drugs with non-standard legal status.

Vinony links it to 6 Wikipedia language editions.

Chemical data

Formula: C44H32N4O4
Molecular weight: 680.7 g/mol
IUPAC name: 3-[10,15,20-tris(3-hydroxyphenyl)-2,3,22,24-tetrahydroporphyrin-5-yl]phenol
SMILES: C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7)O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O
InChIKey: LYPFDBRUNKHDGX-UHFFFAOYSA-N
XLogP: 8.8
Polar surface area: 138 Å²
H-bond donors: 6
H-bond acceptors: 6
Formal charge: 0

via PubChem

Research

558 papers

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 680.242355504
Has use: medication

Show 4 more facts

chemical formula: C₄₄H₃₂N₄O₄
canonical SMILES: C1CC2=NC1=C(C3=CC=C(N3)C(=C4C=CC(=N4)C(=C5C=CC(=C2C6=CC(=CC=C6)O)N5)C7=CC(=CC=C7)O)C8=CC(=CC=C8)O)C9=CC(=CC=C9)O
NCI Thesaurus ID: C1669
subject has role: photosensitizer

Sources (3)

via Wikidata · CC0

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