TRAF4

Also known as CART1, MLN62, RNF83, TNF receptor associated factor 4

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

Gene data

TRAF4

Name: TNF receptor associated factor 4
Type: protein-coding
Position: 28,744,011–28,750,956 (+)
Aliases: CART1, MLN62, RNF83
Ensembl: ENSG00000076604
RefSeq RNA: NM_004295.4, NM_145751.1, XM_011525504.4, XM_011525505.3, XM_011525506.4
RefSeq protein: NP_004286.2, XP_011523806.1, XP_011523807.1, XP_011523808.1, XP_011523809.1

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

Article

3 sections

Contents

Protein interactions
References
Further reading

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins. TRAF proteins connect IL-1R/Toll and TNF receptors with signaling factors that lead to the activation of NF-κB and mitogen-activated protein kinases. However, TRAF4 is not known to interact with TNF receptors and its cellular functions are not well understood.