TRAF4

Name

TNF receptor associated factor 4

Type

protein-coding

Position

28,743,978–28,772,894 (+)

Aliases

CART1, MLN62, RNF83

Ensembl

ENSG00000076604

RefSeq RNA

NM_004295.4, NM_145751.1, XM_011525504.4, XM_011525505.3, XM_011525506.4

RefSeq protein

NP_004286.2, XP_011523806.1, XP_011523807.1, XP_011523808.1, XP_011523809.1

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

TNF receptor associated factor 4

Symbol

TRAF4

Biotype

Protein coding

Organism

Homo sapiens

Location

17:28,743,978-28,772,894

Strand

Forward (+)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein TRAF4 PDB 2EOD.png

via Wikidata · CC0