adrenomedullin
Sign in to saveAlso known as ADM, proadrenomedullin N-20 terminal peptide
thumb|Structure of adrenomedullin Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inf
In the Vinony graph
Vinony's link graph records 369 inbound references to adrenomedullin, and connects out to circulatory system, PubMed and endothelium.
Vinony files it under Endocrinology and Genes on human chromosome 11.
Vinony links it to 11 Wikipedia language editions.
Protein · UniProt
Pro-adrenomedullin
- Gene
- ADM
- Organism
- Homo sapiens (Human)
- Length
- 185 aa
- Molecular mass
- 20,420 Da
- Evidence
- 1: Evidence at protein level
Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents (PubMed:8387282, PubMed:9620797). Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss…
Swiss-Prot (reviewed) · via UniProt
Research
4,304 papers- Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes.Science (New York, N.Y.) · 2025
- Adrenomedullin in pulmonary hypertension.Danish medical journal · 2024
- Adrenomedullin in the eye.Regulatory peptides · 2003
- Adrenomedullin as a Biomarker of Heart Failure.Heart failure clinics · 2018
- [Adrenomedullin].Nihon rinsho. Japanese journal of clinical medicine · 2011
via PubMed
Clinical Trials
27 registered- TERMINATEDIs Bio-adrenomedullin (Bio-ADM) a Prognostic Factor in Patients With COVID-19 Treated in the ICU?Medical University of Warsaw · NCT04813939
- PHASE1COMPLETEDAdrecizumab-LPS StudyAdrenomed AG · NCT03083171
- NAUNKNOWNThe Effects of Exercise on Adipokine in Impaired Fasting Glucose or Impaired Glucose Tolerance PatientsYonsei University · NCT00472342
- COMPLETEDAdrenomedullin in Context With Pulmonary EmbolismUniversity of Pecs · NCT04875130
- PHASE2COMPLETEDTreatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMABAdrenomed AG · NCT03085758
- NACOMPLETEDAdrenomedullin Effect on Migraine Without PatientsDanish Headache Center · NCT04111484
Wikidata facts
- Instance of
- protein
Show 3 more facts
- cell component
- extracellular space
- Commons category
- Adrenomedullin
- found in taxon
- Homo sapiens
Sources (3)
via Wikidata · CC0
~10 min read
Encyclopedic overview
11 sectionsContents
- Structure
- Function
- Receptors
- Clinical significance
- Cardiovascular health
- Gastrointestinal health
- Sepsis
- Tumor angiogenesis
- References
- Further reading
- External links
thumb|Structure of adrenomedullin Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.
In humans, ADM is encoded by the ADM gene. A similar peptide named adreomedullin2 was reported in rats in 2004, which exhibits a similar function.
Excerpted from Wikipedia’s “adrenomedullin” article, available under the CC BY-SA 4.0 licence.