AP2S1

Also known as AP17, CLAPS2, FBH3, FBHOk, HHC3, adaptor related protein complex 2 sigma 1 subunit, adaptor related protein complex 2 subunit sigma 1

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.

Gene data

AP2S1

Name: adaptor related protein complex 2 subunit sigma 1
Type: protein-coding
Position: 46,838,136–46,850,882 (−)
Aliases: AP17, CLAPS2, FBH3, FBHOk, HHC3
Ensembl: ENSG00000042753
RefSeq RNA: NM_001301076.3, NM_001301078.3, NM_001301081.3, NM_004069.6, NM_021575.5
RefSeq protein: NP_001288005.1, NP_001288007.1, NP_001288010.1, NP_004060.2, NP_067586.1

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

intracellular protein transport protein transport vesicle-mediated transport vesicle-mediated transport vesicle-mediated transport regulation of endocytosis clathrin coat assembly synaptic vesicle endocytosis

Molecular function

protein binding clathrin-cargo adaptor activity clathrin-cargo adaptor activity

Cellular component

cytosol plasma membrane plasma membrane cytoplasmic side of plasma membrane membrane membrane coat AP-2 adaptor complex AP-2 adaptor complex

Pathways

Endocytosis - Homo sapiens (human)Synaptic vesicle cycle - Homo sapiens (human)Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)Huntington disease - Homo sapiens (human)Neurotransmitter receptors and postsynaptic signal transmission Transmission across Chemical Synapses Neuronal System Developmental Biology Developmental Biology Adaptive Immune System

via MyGene.info

Gene · Ensembl

adaptor related protein complex 2 subunit sigma 1

Symbol: AP2S1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:46,838,136-46,850,962
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: 2VGL AP-2 complex subunit sigma within the AP2 CLATHRIN ADAPTOR CORE.png

Show 5 more facts

HomoloGene ID: 3001
exact match: identifiers.org/ncbigene/1175
genomic end: 46850846
genomic start: 47341393
cytogenetic location: 19q13.32

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AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.