ARID1B

Name

AT-rich interaction domain 1B

Type

protein-coding

Aliases

6A3-5, BAF250B, BRIGHT, CSS1, DAN15, ELD/OSA1, MRD12, OSA2, P250R, SMARCF2

This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].

via MyGene.info

Gene · Ensembl

AT-rich interaction domain 1B

Symbol

ARID1B

Biotype

Protein coding

Organism

Homo sapiens

Location

6:156,776,020-157,211,460

Strand

Forward (+)

Assembly

GRCh38

• ARID1B-Related Disorder.1993
• The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
• ARID1B-related disorder in 87 adults: Natural history and self-sustainability.Genetics in medicine open · 2024
• ARID1B maintains mesenchymal stem cell quiescence via inhibition of BCL11B-mediated non-canonical Activin signaling.Nature communications · 2024
• Neurobiology of ARID1B haploinsufficiency related to neurodevelopmental and psychiatric disorders.Molecular psychiatry · 2022

via PubMed

Wikidata facts

Image

Protein ARID1B PDB 2cxy.png

via Wikidata · CC0