ARNT

Name

aryl hydrocarbon receptor nuclear translocator

Type

protein-coding

Position

150,808,617–150,876,771 (−)

Aliases

ARNT1, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2

Ensembl

ENSG00000143437

RefSeq RNA

NM_001197325.2, NM_001286035.2, NM_001286036.2, NM_001350224.2, NM_001350225.2

RefSeq protein

NP_001184254.1, NP_001272964.1, NP_001272965.1, NP_001337153.1, NP_001337154.1

This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013].

via MyGene.info

Gene · Ensembl

aryl hydrocarbon receptor nuclear translocator

Symbol

ARNT

Biotype

Protein coding

Organism

Homo sapiens

Location

1:150,808,617-150,876,771

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ARNT PDB 1x0o.png

via Wikidata · CC0