BIRC3

Name

baculoviral IAP repeat containing 3

Type

protein-coding

Position

102,317,484–102,339,403 (+)

Aliases

AIP1, API2, CIAP2, HAIP1, HIAP1, IAP-1, MALT2, MIHC, RNF49, c-IAP2

Ensembl

ENSG00000023445

RefSeq RNA

NM_001165.5, NM_182962.3, XM_054368613.1

RefSeq protein

NP_001156.1, NP_892007.1, XP_054224588.1

This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011].