carprofen

Also known as Ro-205720000, 6-chloro-alpha-methyl-9H-carbazole-2-acetic acid, (+-)-6-chloro-alpha-methylcarbazole-2-acetic acid, 2-(6-Chloro-9H-carbazol-2-yl)-propionic acid, 6-chloro-alpha-Methyl-9H-carbazole-2-acetic acid, Carprofène, (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid

thumb|100px|A 100 Kilogram#SI multiples|mg Rimadyl tablet approximately wide by thick, as sold in the USA.

Key facts

Drug.PubChem: 2581
Drug.Watchedfields: changed
Drug.verifiedrevid: 460020416
Drug.image: Carprofen.svg
Drug.image_class: skin-invert-image
Drug.width: 280
Drug.alt: Two-dimensional monochrome diagram showing the structure of the molecule of Carprofen, uing the hexagonal style to depict a chemical compound.
Drug.caption: Carprofen molecule
Drug.chirality: Racemic mixture
Drug.tradename: Rimadyl, others
Drug.DailyMedID: Carprofen
Drug.routes_of_administration: By mouth, injection
Drug.ATCvet: yes
Drug.ATC_prefix: M01
Drug.ATC_suffix: AE91
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.protein_bound: High (99%)

via Wikipedia infobox

Research

797 papers

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and carprofen in dogs undergoing ovariohysterectomy.PloS one · 2020
Efficacy of meloxicam compared with carprofen for treating canine osteoarthritis.The Veterinary record · 2020
Use of carprofen for the treatment of pain and inflammation in dogs.Journal of the American Veterinary Medical Association · 1997
Pharmacokinetics and bioavailability of carprofen in sheep.Journal of veterinary pharmacology and therapeutics · 2022
Carprofen: a new nonsteroidal antiinflammatory drug. Pharmacology, clinical efficacy and adverse effects.Pharmacotherapy · 1987

via PubMed

Wikidata facts

Mass: 273.056

Show 4 more facts

chemical formula: C₁₅H₁₂ClNO₂
canonical SMILES: CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O
World Health Organisation international non-proprietary name: carprofen
Commons category: Carprofen

Sources (3)

via Wikidata · CC0

~6 min read

Article

9 sections

Contents

Human use
Veterinary medicine
Canine use
Adverse effects
Equine use
Other animal use
Brands and dosage forms for veterinary use
References
External links

thumb|100px|A 100 Kilogram#SI multiples|mg Rimadyl tablet approximately wide by thick, as sold in the USA.

Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in animals. Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. Marketed under many brand names worldwide, carprofen is used as a treatment for inflammation and pain, including joint pain and postoperative pain.