cellular glucuronidation
Sign in to saveAlso known as GO:0052695, cellular glucuronoside biosynthesis, cellular glucuronide biosynthesis, cellular glucuronoside biosynthetic process, cellular glucuronide biosynthetic process, Glucuronidation
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.
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Within Vinony's link graph, cellular glucuronidation is referenced by 287 other articles, and connects out to drug metabolism, glucuronosyltransferase and water.
It sits within the topics Hepatology and Organic reactions.
Its subject is documented across 10 Wikipedia language editions.
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- Instance of
- biological process
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- purl.obolibrary.org/obo/GO_0052695
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Encyclopedic overview
5 sectionsContents
- Mechanism
- Sites
- General influencing factors
- Affected drugs
- References
Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages involve glycosidic bonds.
==Mechanism== Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase. UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) is an intermediate in the process and is formed in the liver. One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver. 500px
Excerpted from Wikipedia’s “cellular glucuronidation” article, available under the CC BY-SA 4.0 licence.
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