Structure via PubChem · Public domain (PubChem)
chlorthalidone
Sign in to saveAlso known as HYT182, G-33182, Hygroton®, Chlortalidone, phthalamudine, phthalamodine, chlorphthalidolone, 1-keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug used to treat high blood pressure, swelling (such as occurs in heart failure, liver failure, and nephrotic syndrome), diabetes insipidus, and renal tubular acidosis. Because chlortalidone is effective in most patients with high blood pressure, it is considered a preferred initial treatment. It is also used to prevent calcium-based kidney stones. It is taken by mouth. Effects generally begin within three hours and last for up to three days. Long-term treatment with chlortalidone is more effective than hydrochlorothiaz
In the Vinony graph
Within Vinony's link graph, chlorthalidone is referenced by 120 other articles, and connects out to collecting duct system, arterial hypertension and kidney stone disease.
It sits within the topics Carbonic anhydrase inhibitors, Chloroarenes and Diuretics.
Its subject is documented across 22 Wikipedia language editions.
Chemical data
- Formula
- C14H11ClN2O4S
- Molecular weight
- 338.8 g/mol
- IUPAC name
- 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
- SMILES
- C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
- InChIKey
- JIVPVXMEBJLZRO-UHFFFAOYSA-N
- XLogP
- 0.9
- Polar surface area
- 118 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1960
- Admin. routes
- oral
- Indications
- hypertension, cardiovascular disease, cerebrovascular disorder, heart disease
via ChEMBL · EBI
Research
2,098 papers- Chlorthalidone as Secondary Treatment in HFpEF?The American journal of medicine · 2025
- [Which is better? Chlorthalidone or Hydrochlorothiazide].MMW Fortschritte der Medizin · 2023
- Chlorthalidone in advanced CKD.Nature reviews. Nephrology · 2022
- Azilsartan and Chlorthalidone-new Powerful Fixed dose Antihypertensive Combination.Current hypertension reviews · 2018
- Chlorthalidone: the forgotten diuretic.Postgraduate medicine · 2012
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 338.013
- Has use
- medication
Show 7 more facts
- medical condition treated
- nephrogenic diabetes insipidus
- chemical formula
- C₁₄H₁₁ClN₂O₄S
- World Health Organisation international non-proprietary name
- chlortalidone
- canonical SMILES
- C1=CC=C2C(=C1)C(=O)NC2(C3=CC(=C(C=C3)Cl)S(=O)(=O)N)O
- defined daily dose
- 25
- Commons category
- Chlortalidone
- significant drug interaction
- bromocriptine
Sources (6)
via Wikidata · CC0
~12 min read
Encyclopedic overview
14 sectionsContents
- Medical use
- High blood pressure
- Left ventricular hypertrophy
- Swelling
- Bone fracture prevention
- Kidney stone prevention
- Ménière's disease
- Diabetes insipidus
- Adverse effects
- Mechanism of action
- Pharmacokinetics
- Chemistry
- Society and culture
- References
Chlortalidone, also known as chlorthalidone, is a thiazide-like diuretic drug used to treat high blood pressure, swelling (such as occurs in heart failure, liver failure, and nephrotic syndrome), diabetes insipidus, and renal tubular acidosis. Because chlortalidone is effective in most patients with high blood pressure, it is considered a preferred initial treatment. It is also used to prevent calcium-based kidney stones. It is taken by mouth. Effects generally begin within three hours and last for up to three days. Long-term treatment with chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke.
Common adverse effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction. Other adverse effects may include gout, low blood magnesium, high blood calcium, allergic reactions, and low blood pressure. Some reviews have found chlortalidone and hydrochlorothiazide to have a similar risk of adverse effects, while other reviews have found chlortalidone to have a higher risk. While it may be used in pregnancy it is a less preferred option. How it works is not completely clear but is believed to involve increasing the amount of sodium and water lost by the kidneys.
Excerpted from Wikipedia’s “chlorthalidone” article, available under the CC BY-SA 4.0 licence.